RT Journal Article
SR Electronic
T1 Clinical delineation of myasthenia gravis in the Kingdom of Bahrain
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 16
OP 23
DO 10.17712/nsj.2022.1.20210096
VO 27
IS 1
A1 Mohamed F. Binfalah
A1 Hussein H. Alhafnawi
A1 Ahmed A. Jaradat
A1 Eslam Shosha
A1 Ali J. Alhilly
A1 Firas K. Al Nidawi
A1 Mariam M. Alhammadi
A1 Moiz O. Bakhiet
A1 Fatema M. Abdulla
YR 2022
UL http://nsj.org.sa/content/27/1/16.abstract
AB Objectives: To report demographic and clinical data on 98 myasthenia gravis (MG) patients, seen over 5 years (January 2014-December 2018).Methods: This was a retrospective, observational cohort study carried out at 3 hospitals in Bahrain. MG was classified into ocular or generalized types. We subdivided MG into early-onset (EOMG, ≤ 49 years) or late-onset (LOMG, > 49 years). Demographic and clinical data were recorded. The data was entered and analyzed using SPSS version 26.0.Results: 61.2% were females. The mean age at onset was 43.8±17.7 years in males and 43.1±15.7 years in females. 72.4% had EOMG. A pure ocular presentation was most common (51%). Limb weakness was more prevalent in AChR-positive patients. The MuSK group had more severe presentation. 57.1% of patients were AChR-positive, 3.1% MuSK-positive, and 39.8% double-seronegative. Generalized disease onset was more likely with AChR. Abnormal CT chest was seen in 24/69 (35%) including thymic hyperplasia, thymoma, and thymic atrophy. Pathology findings were thymic hyperplasia (55.0%), thymoma (30%), thymolipoma (10%), and normal thymus (5%). Treatment outcomes were favorable.Conclusion: The present study revealed that MG was more common in females, with similar age at onset between males and females. The majority of patients had EOMG with ocular disease and AChR positivity. The clinical outcomes were favorable. Following a standardized protocol for MG diagnosis and workup is recommended.