PT  - JOURNAL ARTICLE
AU  - Ghalib M. Alanazi
AU  - Turki F. ALOsaimi
AU  - Ali H. Alwadei
AU  - Ali D. Al-Otaibi
AU  - Lamya A. Jad
AU  - Alawi A. Al-Attas
TI  - Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome
AID  - 10.17712/nsj.2022.2.20210135
DP  - 2022 Apr 01
TA  - Neurosciences Journal
PG  - 59--64
VI  - 27
IP  - 2
4099  - http://nsj.org.sa/content/27/2/59.short
4100  - http://nsj.org.sa/content/27/2/59.full
SO  - Neurosciences (Riyadh)2022 Apr 01; 27
AB  - Objectives: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome.Methods: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox–Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8±1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8±3.9 years were implanted with VNS stimulators.Results: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75% seizure reduction in more than 50% in one, and greater than 25% in 2 respectively. However, in those implanted with VNS, 2 (50%) patients achieved a reduction in seizure frequency of greater than 75% and 2 (50%) greater than 25%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS.Conclusion: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients.