Table 2

- Clinical characteristics.

Patient / Clinical diagnosis	EEG	Brain imaging	Development
Microcephaly	Focal discharges	Normal	Cognitive delay
Focal epilepsy	Focal discharges	Lissencephaly	GDD*
Meningitis (HSV meningitis)	Generalized epileptic discharges	Atrophy	GDD
Focal epilepsy	Focal discharges	Normal	Normal
Focal epilepsy	Focal discharges	Sturge weber syndrome	Mild hemiparesis
Infantile spasms, congenital Muscular dystrophy	Hypsarrhythmia	Hydrocephalus, Muscle eye brain disease	GDD
Hydrocephalus	Slow background	Hydrocephalus and brain tumor (astrocytoma)	GDD
Noonan syndrome and infantile spasms	Hypsarrhythmia	Normal	GDD
Epilepsy (genetic), infantile spasms, panhypopituitarism	Hypsarrhythmia	brain atrophy & corpus callosum agenesis also panhypopituraism	GDD
Meningoencephalitis	Generalized epileptic discharges	Atrophy and cystic encephalomalacia	Normal
VP shunt hydrocephalus	Generalized epileptic discharges	Hydrocephalus & Chiari malformation type 2	GDD
VP shunt Hydrocephalus	Generalized epileptic discharges	Hydrocephalus	GDD
Metabolic, aminoacidopathy	Encephalopathy	Normal	Normal
Down syndrome & congenital heart disease	Focal epileptic discharges	Enlarged ventricles	Cognitive delay
Focal seizures	Slow background	Normal	Normal
GM1 gangliosidosis	Slow background	Brain atrophy	GDD
Meningoencephalitis	Generalized epileptic discharges	Normal	Normal
Mitochondrial disease	Encephalopathy	Mitochondrial disease (leigh disease)	GDD
Idiopathic epilepsy	Slow background	Normal	Normal
Infantile spasms	Hypsarrhythmia	Hypoxic ischemic encephalopathy	GDD
Birth asphyxia	Generalized epileptic discharges	Periventricular leukomalacia	GDD
NCL* type 14	Generalized epileptic discharges	Brain atrophy	GDD
Down syndrome	Encephalopathy	Hypoxic ischemic encephalopathy	GDD
Birth asphyxia. Lennox-Gastaut syndrome	Generalized epileptic discharges	Hypoxic ischemic encephalopathy & brain atrophy	GDD
Idiopathic epilepsy	Encephalopathy	Normal	Normal
Down syndrome and generalized epilepsy	Slow background	Normal	GDD
Wolf-Hirschhorn syndrome (chromosome 4P deletion), hypotonia, meningitis, myoclonic epilepsy	Generalized epileptic discharges	Meningitis and agenesis of corpus callosum	GDD
Birth asphyxia. Lennox-Gastaut syndrome	Generalized epileptic discharges	Occipital encephalomalacia	GDD
Brain tumor	Focal discharges	Brain tumor (Dysembryoplastic neuroepithelial)	Normal

GDD - Global developmental delay, HSV - herpes simplex virus, GM1 - gangliosidosis 1, NCL - neuronal ceroid lipofuscinosis