- Systematic literature review.
| Author | Year | No. of LGS patients | Surgical approach | Outcome of interest | Reported adverse event | Seizure reduction |
|---|---|---|---|---|---|---|
| Aaron E.L. Warren | 2022 | 20 | Targeting CMN | Optimal target and connectivity for DBS in LGS | N=1 cerebral infection | >52% |
| Byung-chul Son | 2016 | 4 | Targeting CMN | Clinical outcomes and location of active contacts | N=1 Misplacement of bilateral DBS leads | 30% -100% |
| F. Velasco | 2007 | 26 | Targeting CMN | Clinical outcomes and location of active contacts | None | 53% - 100% |
LGS -Lennox-Gastaut syndrome, CMN - centromedian thalamic nucleus, DBS - deep brain stimulation