- Characteristics of 4 patients with H3F3A-mutant M-HGGs.
| No. | Age (y) | Sex | Histo-diagnosis | No. of lesions | Location | H3F3A | IDH | TERT | MGMT | Treatment | PFS (mo.) | OS (mo.) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 27 | F | GBM | 2 | FL+TL+PL, R | H3G34R | wt | wt | met | STR+RT(66Gy)+TMZ | 13 | 16 |
| 2 | 65 | F | HGG | 2 | BG+TH, R | H3K27 M | wt | wt | met | Biopsy+RT(60Gy)+TMZ | 11 | 14 |
| 3 | 37 | M | AA | 3 | FL+TH, B | H3K27 M | wt | wt | unmet | Biopsy+RT(54Gy) | 8 | 15 |
| 4 | 35 | M | HGG | 2 | TL+BG+TH, R | H3K27 M | wt | wt | unmet | Biopsy+RT(60Gy)+TTF | 6 | 7 |
M - male; F - female; GBM - glioblastoma; HGG - high-grade glioma; AA - anaplastic astrocytoma; FL - frontal lobe; PL - parietal lobe; TH - thalamus; TL - temporal lobe; BG - basal ganglia; R - right; L - left; B - bilateral; wt - wild-type; met - methylated; unme t- unmethylated; STR - subtotal resection; RT - radiotherapy; TMZ - temozolomide; TTF - tumor-treating fields; mo - month(s)