Skip to main content

Advertisement

SpringerLink
Log in

Childhood and juvenile meningiomas

  • Original Paper
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this paper was to study the clinical characteristic, treatment, and prognosis of childhood meningioma.

Materials and methods

Fifty-four meningioma cases below the age of 18 have been treated in Huashan Hospital in the last 15 years (from 1993 to 2008), their sex and age distribution, clinical manifestation, radiological finding, pathological subtype, treatment, and prognosis are retrospectively analyzed, and the results are compared with those reported in the literature.

Results

The ratio of male to female was 1.16:1 (29:25) and mean age was 13.14 years (ranging from 2.75 to 18 years). Five patients in this series were associated with neurofibromatosis-2. The most common symptoms and signs were the signs of increased intracranial pressure including headache, papilledema, and vomiting. The most common radiological finding was homogeneous enhancement with contrast. The most common locations of meningiomas in this series were intraventricular and anterior/middle fossa. All of these patients were surgically treated; resection both in Simpson grades I and II could be achieved in 39 out of 54 patients. Perioperative mortality was 3.7% (2 out of 54); the most common postoperative complications were intracranial infection and injury of cranial nerve. Fibroblastic meningiomas were the most common pathological subtype, and malignant and atypical meningiomas (both of grades II and III according to WHO classification) accounted for 18.5% of the whole series.

Conclusion

Childhood meningiomas are scarce in clinical practice, which are characterized with its male predominance, large size, distinctive radiological features, and high rate of atypical/malignant histological subtypes; favorable outcome is accessible with total removal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Reference

  1. Bondy M, Ligon BL (1996) Epidemiology and etiology of intracranial meningiomas: a review. J Neurooncol 29:197–205 discussion 140–131

    Article  CAS  PubMed  Google Scholar 

  2. Erdincler P, Lena G, Sarioglu AC, Kuday C, Choux M (1998) Intracranial meningiomas in children: review of 29 cases. Surg Neurol 49:136–140

    Article  CAS  PubMed  Google Scholar 

  3. Herz DA, Shapiro K, Shulman K (1980) Intracranial meningiomas of infancy, childhood and adolescence. Review of the literature and addition of 9 case reports. Childs Brain 7:43–56

    CAS  PubMed  Google Scholar 

  4. Im SH, Wang KC, Kim SK, Oh CW, Kim DG, Hong SK, Kim NR, Chi JG, Cho BK (2001) Childhood meningioma: unusual location, atypical radiological findings, and favorable treatment outcome. Childs Nerv Syst 17:656–662

    Article  CAS  PubMed  Google Scholar 

  5. Leibel SA, Wara WM, Sheline GE, Townsend JJ, Boldrey EB (1976) The treatment of meningiomas in childhood. Cancer 37:2709–2712

    Article  CAS  PubMed  Google Scholar 

  6. Mehrazin M, Yavari P (2007) Morphological pattern and frequency of intracranial tumors in children. Childs Nerv Syst 23:157–162

    Article  CAS  PubMed  Google Scholar 

  7. Tufan K, Dogulu F, Kurt G, Emmez H, Ceviker N, Baykaner MK (2005) Intracranial meningiomas of childhood and adolescence. Pediatr Neurosurg 41:1–7

    Article  PubMed  Google Scholar 

  8. Caroli E, Russillo M, Ferrante L (2006) Intracranial meningiomas in children: report of 27 new cases and critical analysis of 440 cases reported in the literature. J Child Neurol 21:31–36

    Article  PubMed  Google Scholar 

  9. Arivazhagan A, Devi BI, Kolluri SV, Abraham RG, Sampath S, Chandramouli BA (2008) Pediatric intracranial meningiomas—do they differ from their counterparts in adults? Pediatr Neurosurg 44:43–48

    Article  CAS  PubMed  Google Scholar 

  10. Liu Y, Li F, Zhu S, Liu M, Wu C (2008) Clinical features and treatment of meningiomas in children: report of 12 cases and literature review. Pediatr Neurosurg 44:112–117

    Article  PubMed  Google Scholar 

  11. Hughes IA, Kumanan M (2006) A wider perspective on puberty. Mol Cell Endocrinol 254–255:1–7

    Article  PubMed  Google Scholar 

  12. Choudhary A, Pradhan S, Huda MF, Mohanty S, Kumar M (2006) Radiation induced meningioma with a short latent period following high dose cranial irradiation—case report and literature review. J Neurooncol 77:73–77

    Article  PubMed  Google Scholar 

  13. Abhaya V, Kulkarni PM (2006) Meningiomas. In: Tonn J-C, Westphal M, Rutka JT, Grossman SA (eds) Neuro-onclology of CNS tumors. Springer, Berlin, pp 486–490

    Google Scholar 

  14. Schoemaker MJ, Swerdlow AJ, Hepworth SJ, van Tongeren M, Muir KR, McKinney PA (2007) History of allergic disease and risk of meningioma. Am J Epidemiol 165:477–485

    Article  CAS  PubMed  Google Scholar 

  15. Rochat P, Johannesen HH, Gjerris F (2004) Long-term follow up of children with meningiomas in Denmark: 1935 to 1984. J Neurosurg 100:179–182

    PubMed  Google Scholar 

  16. Amirjamshidi A, Mehrazin M, Abbassioun K (2000) Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature. Childs Nerv Syst 16:406–416

    Article  CAS  PubMed  Google Scholar 

  17. Perilongo G, Sutton LN, Goldwein JW, Gusnard D, Schut L, Biegel JA, Rorke LB, Lange B, D'Angio GJ (1992) Childhood meningiomas. Experience in the modern imaging era. Pediatr Neurosurg 18:16–23

    Article  CAS  PubMed  Google Scholar 

  18. Zwerdling T, Dothage J (2002) Meningiomas in children and adolescents. J Pediatr Hematol Oncol 24:199–204

    Article  PubMed  Google Scholar 

  19. Deen HG Jr, Scheithauer BW, Ebersold MJ (1982) Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg 56:317–322

    Article  PubMed  Google Scholar 

  20. Germano IM, Edwards MS, Davis RL, Schiffer D (1994) Intracranial meningiomas of the first two decades of life. J Neurosurg 80:447–453

    Article  CAS  PubMed  Google Scholar 

  21. Mallucci CL, Parkes SE, Barber P, Powell J, Stevens MC, Walsh AR, Hockley AD (1996) Paediatric meningeal tumours. Childs Nerv Syst 12:582–588 discussion 589

    Article  CAS  PubMed  Google Scholar 

  22. Sheikh BY, Siqueira E, Dayel F (1996) Meningioma in children: a report of nine cases and a review of the literature. Surg Neurol 45:328–335

    Article  CAS  PubMed  Google Scholar 

  23. Kolluri VR, Reddy DR, Reddy PK, Naidu MR, Rao SB, Sumathi C (1987) Meningiomas in childhood. Childs Nerv Syst 3:271–273

    Article  CAS  PubMed  Google Scholar 

  24. Turgut M, Ozcan OE, Bertan V (1997) Meningiomas in childhood and adolescence: a report of 13 cases and review of the literature. Br J Neurosurg 11:501–507

    Article  CAS  PubMed  Google Scholar 

  25. Whittle IR, Smith C, Navoo P, Collie D (2004) Meningiomas. Lancet 363:1535–1543

    Article  PubMed  Google Scholar 

  26. Yoon HK, Kim SS, Kim IO, Na DG, Byun HS, Shin HJ, Han BK (1999) MRI of primary meningeal tumours in children. Neuroradiology 41:512–516

    Article  CAS  PubMed  Google Scholar 

  27. Inamura T, Nishio S, Takeshita I, Fujiwara S, Fukui M (1992) Peritumoral brain edema in meningiomas—influence of vascular supply on its development. Neurosurgery 31:179–185

    Article  CAS  PubMed  Google Scholar 

  28. Kalkanis SN, Carroll RS, Zhang J, Zamani AA, Black PM (1996) Correlation of vascular endothelial growth factor messenger RNA expression with peritumoral vasogenic cerebral edema in meningiomas. J Neurosurg 85:1095–1101

    Article  CAS  PubMed  Google Scholar 

  29. Lobato RD, Alday R, Gomez PA, Rivas JJ, Dominguez J, Cabrera A, Madero S, Ayerbe J (1996) Brain oedema in patients with intracranial meningioma. Correlation between clinical, radiological, and histological factors and the presence and intensity of oedema. Acta Neurochir (Wien) 138:485–493 discussion 493–484

    Article  CAS  Google Scholar 

  30. Maiuri F, Gangemi M, Cirillo S, Delehaye L, Gallicchio B, Carandente M, Giamundo A (1987) Cerebral edema associated with meningiomas. Surg Neurol 27:64–68

    Article  CAS  PubMed  Google Scholar 

  31. de Vries J, Wakhloo AK (1993) Cerebral oedema associated with WHO-I, WHO-II, and WHO-III-meningiomas: correlation of clinical, computed tomographic, operative and histological findings. Acta Neurochir (Wien) 125:34–40

    Article  Google Scholar 

  32. Di Rocco C, Di Rienzo A (1999) Meningiomas in childhood. Crit Rev Neurosurg 9:180–188

    Article  PubMed  Google Scholar 

  33. Ferrante L, Acqui M, Artico M, Mastronardi L, Rocchi G, Fortuna A (1989) Cerebral meningiomas in children. Childs Nerv Syst 5:83–86

    Article  CAS  PubMed  Google Scholar 

  34. Perry A, Giannini C, Raghavan R, Scheithauer BW, Banerjee R, Margraf L, Bowers DC, Lytle RA, Newsham IF, Gutmann DH (2001) Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases. J Neuropathol Exp Neurol 60:994–1003

    CAS  PubMed  Google Scholar 

  35. Begnami MD, Rushing EJ, Santi M, Quezado M (2007) Evaluation of NF2 gene deletion in pediatric meningiomas using chromogenic in situ hybridization. Int J Surg Pathol 15:110–115

    Article  CAS  PubMed  Google Scholar 

  36. Chan RC, Thompson GB (1984) Intracranial meningiomas in childhood. Surg Neurol 21:319–322

    Article  CAS  PubMed  Google Scholar 

  37. Ko KW, Nam DH, Kong DS, Lee JI, Park K, Kim JH (2007) Relationship between malignant subtypes of meningioma and clinical outcome. J Clin Neurosci 14:747–753

    Article  PubMed  Google Scholar 

  38. Hsu DW, Efird JT, Hedley-Whyte ET (1998) MIB-1 (Ki-67) index and transforming growth factor-alpha (TGF alpha) immunoreactivity are significant prognostic predictors for meningiomas. Neuropathol Appl Neurobiol 24:441–452

    Article  CAS  PubMed  Google Scholar 

  39. Vankalakunti M, Vasishta RK, Das Radotra B, Khosla VK (2007) MIB-1 immunolabeling: a valuable marker in prediction of benign recurring meningiomas. Neuropathology 27:407–412

    Article  PubMed  Google Scholar 

  40. Karamitopoulou E, Perentes E, Tolnay M, Probst A (1998) Prognostic significance of MIB-1, p53, and bcl-2 immunoreactivity in meningiomas. Hum Pathol 29:140–145

    Article  CAS  PubMed  Google Scholar 

  41. Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM (1998) The prognostic significance of MIB-1, p53, and DNA flow cytometry in completely resected primary meningiomas. Cancer 82:2262–2269

    Article  CAS  PubMed  Google Scholar 

  42. Terzi A, Saglam EA, Barak A, Soylemezoglu F (2008) The significance of immunohistochemical expression of Ki-67, p53, p21, and p16 in meningiomas tissue arrays. Pathol Res Pract 204:305–314

    Article  PubMed  Google Scholar 

  43. Kamei Y, Watanabe M, Nakayama T, Kanamaru K, Waga S, Shiraishi T (2000) Prognostic significance of p53 and p21WAF1/CIP1 immunoreactivity and tumor micronecrosis for recurrence of meningiomas. J Neurooncol 46:205–213

    Article  CAS  PubMed  Google Scholar 

  44. Lanzafame S, Torrisi A, Barbagallo G, Emmanuele C, Alberio N, Albanese V (2000) Correlation between histological grade, MIB-1, p53, and recurrence in 69 completely resected primary intracranial meningiomas with a 6 year mean follow-up. Pathol Res Pract 196:483–488

    CAS  PubMed  Google Scholar 

  45. Ohkoudo M, Sawa H, Hara M, Saruta K, Aiso T, Ohki R, Yamamoto H, Maemura E, Shiina Y, Fujii M, Saito I (1998) Expression of p53, MDM2 protein and Ki-67 antigen in recurrent meningiomas. J Neurooncol 38:41–49

    Article  CAS  PubMed  Google Scholar 

  46. Wang JL, Zhang ZJ, Hartman M, Smits A, Westermark B, Muhr C, Nister M (1995) Detection of TP53 gene mutation in human meningiomas: a study using immunohistochemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples. Int J Cancer 64:223–228

    Article  CAS  PubMed  Google Scholar 

  47. Harris AE, Lee JY, Omalu B, Flickinger JC, Kondziolka D, Lunsford LD (2003) The effect of radiosurgery during management of aggressive meningiomas. Surg Neurol 60:298–305 discussion 305

    Article  PubMed  Google Scholar 

  48. Iwai Y, Yamanaka K, Morikawa T (2004) Adjuvant gamma knife radiosurgery after meningioma resection. J Clin Neurosci 11:715–718

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fu Dan University, #12 Wulumuqi Zhong Road, Shanghai, 200040, China

    Xing Gao, Rong Zhang & Ying Mao

  2. Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fu Dan University, Shanghai, China

    Yin Wang

Authors
  1. Xing Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ying Mao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yin Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rong Zhang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gao, X., Zhang, R., Mao, Y. et al. Childhood and juvenile meningiomas. Childs Nerv Syst 25, 1571–1580 (2009). https://doi.org/10.1007/s00381-009-0964-x

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-009-0964-x

Keywords

Search

Navigation