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The role of cytokines in Guillain–Barré syndrome

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Abstract

Cytokines play an important role in the pathogenesis of autoimmune diseases including Guillain–Barré syndrome (GBS) and its animal model experimental autoimmune neuritis (EAN). In this article, we reviewed the current knowledge of the role of cytokines such as TNF-α, IFN-γ, IL-1β, IL-6, IL-12, IL-18, IL-23, IL-17, IL-10, IL-4 and chemokines in GBS and EAN as unraveled by studies both in the clinic and the laboratory. However, these studies occasionally yield conflicting results, highlighting the complex role that cytokines play in the disease process. Efforts to modulate cytokine function in GBS and other autoimmune disease have shown efficiency indicating that cytokines are important therapeutic targets.

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Acknowledgments

The studies of the authors referred to in this review were supported by grants from the Swedish Research Council (K2007-62X-13133-09-3) and from ALF-project grant of Karolinska Institute University Hospital, Stockholm, Sweden and grant from Swedish Medical Association.

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  1. Department of Neurology, The First Hospital, Jilin University, Xinmin Street No.17, Changchun, China

    Ming-Ou Lu & Jie Zhu

  2. Department of Neurology, The First Hospital, Dalian Medical University, Zhongshan Road 222, Dalian, China

    Ming-Ou Lu

  3. Division of Neurodegeneration (NOVUM, plan 5), Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital in Huddinge, 141 86, Stockholm, Sweden

    Jie Zhu

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  1. Ming-Ou Lu
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Correspondence to Jie Zhu.

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Lu, MO., Zhu, J. The role of cytokines in Guillain–Barré syndrome. J Neurol 258, 533–548 (2011). https://doi.org/10.1007/s00415-010-5836-5

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