Abstract
We report two cases of brain abscesses caused by Ramichloridium mackenziei, a neurotropic dematiaceous fungus that seems to be geographically restricted to the Middle East. One of the patients had chronic myelomonocytic leukemia but did not receive any chemotherapeutic agents. The other patient was a normal host. Both cases had a fatal outcome despite aggressive antifungal therapy and surgical intervention. Herein, we review all previously described cases in the literature, and discuss the epidemiology, mycology and histopathology of this life-threatening organism.
MeSH terms
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Adult
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Aged
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Antifungal Agents / therapeutic use
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Ascomycota* / isolation & purification
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Ascomycota* / pathogenicity
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Brain Abscess / complications
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Brain Abscess / microbiology*
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Brain Abscess / pathology
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Brain Abscess / therapy
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Central Nervous System Fungal Infections / complications
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Central Nervous System Fungal Infections / microbiology*
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Central Nervous System Fungal Infections / pathology
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Central Nervous System Fungal Infections / therapy
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Fatal Outcome
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Frontal Lobe / microbiology*
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Humans
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Leukemia, Myelomonocytic, Chronic / complications
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Male
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Middle East / epidemiology
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Mycoses / complications
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Mycoses / microbiology*
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Mycoses / pathology
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Mycoses / therapy
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Parietal Lobe / microbiology*
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Tomography, X-Ray Computed