Modeling axonal degeneration within the anterior visual system: implications for demonstrating neuroprotection in multiple sclerosis

Arch Neurol. 2008 Jan;65(1):26-35. doi: 10.1001/archneurol.2007.10.

Abstract

A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Evoked Potentials, Visual / physiology
  • Humans
  • Magnetic Resonance Imaging
  • Multiple Sclerosis / pathology*
  • Multiple Sclerosis / physiopathology
  • Nerve Degeneration / pathology*
  • Nerve Degeneration / physiopathology
  • Optic Disk / pathology
  • Optic Nerve / pathology
  • Optic Neuritis / pathology
  • Reflex, Pupillary / physiology
  • Visual Pathways / pathology*
  • Visual Pathways / physiopathology