Damage to memory circuits may lead to dementia symptoms in Alzheimer's disease (AD)
and Parkinson's disease dementia (PDD). Recently, deep brain stimulation (DBS) has been …

Oculopharyngodistal myopathy is a late-onset degenerative muscle disorder characterized
by ptosis and weakness of the facial, pharyngeal, and distal limb muscles. A recent report …

Mutations in the m.13094T>C MT-ND5 gene have been previously described in three cases
of Leigh Syndrome (LS). In this retrospective, international cohort study we identified 20 …

Background and Purpose Nicotinic ACh receptors containing the α7 sub‐unit (α7‐nAChRs)
suppress inflammation through a wide range of pathways in immune cells. These receptors …

Background and Purpose— Studies on the prevalence and risk factors of white matter
lesions (WMLs) in Tibetans living at high altitudes are scarce. We conducted this study to …

The m.3243A >G mutation in the tRNA Leu (UUR) gene (MT-TL1) of the mitochondrial DNA
is the most widely seen pathogenic mtDNA mutation which has major phenotypic variations. …

The m.3243A > G mutation in the mitochondrial tRNA Leu (UUR) gene is associated with a
variety of phenotypic heterogeneity. The clinical spectrum and phenotypic-genotypic …

Background: The increasing prevalence of Alzheimer's disease (AD) has emerged as a major
challenge worldwide. China as the most populous country in the globe is amid rapid aging …

Proper intracellular localization of TLRs is essential for their signaling and biological function.
Endocytosis constitutes a key step in protein turnover, as well as maintenance of TLR …

Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as
fatigable muscle weakness, which is typically caused by pathogenic autoantibodies against …