Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304
Objective: To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive
α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, …
α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, …
Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures
…, M Endziniene, Z Hong, J French, H Yang… - Neurology, 2012 - AAN Enterprises
Objective: To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1–3
concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures. …
concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures. …
Evaluation of adjunctive perampanel in patients with refractory partial‐onset seizures: results of randomized global phase III study 305
…, GL Krauss, BJ Steinhoff, D Squillacote, H Yang… - …, 2013 - Wiley Online Library
Purpose: To assess the efficacy and safety of once‐daily doses of perampanel 8 and 12 mg
when added to 1–3 concomitantly administered, approved antiepileptic drugs (AEDs) in …
when added to 1–3 concomitantly administered, approved antiepileptic drugs (AEDs) in …
Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pooled analysis of three phase III studies
…, L Kramer, A Satlin, D Squillacote, H Yang… - …, 2013 - Wiley Online Library
… Lynn Kramer, Andrew Satlin, David Squillacote, Haichen Yang, Jin Zhu, and Antonio Laurenza
are employees of Eisai Inc. We confirm that we have read the Journal's position on issues …
are employees of Eisai Inc. We confirm that we have read the Journal's position on issues …
Psychiatric and behavioral adverse events in randomized clinical studies of the noncompetitive AMPA receptor antagonist perampanel
AB Ettinger, A LoPresti, H Yang, B Williams, S Zhou… - …, 2015 - Wiley Online Library
Objective Perampanel, a selective, noncompetitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic
acid (AMPA) glutamate receptor antagonist, is indicated for adjunctive treatment …
acid (AMPA) glutamate receptor antagonist, is indicated for adjunctive treatment …
Perampanel, a selective, noncompetitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial …
…, P Kwan, JJ Shih, D Squillacote, H Yang… - …, 2013 - Wiley Online Library
Purpose: To evaluate safety, tolerability, and seizure outcome data during long‐term treatment
with once‐daily adjunctive perampanel (up to 12 mg/day) in patients with refractory partial…
with once‐daily adjunctive perampanel (up to 12 mg/day) in patients with refractory partial…
Neurocognitive effects of adjunctive levetiracetam in children with partial‐onset seizures: A randomized, double‐blind, placebo‐controlled, noninferiority trial
PM Levisohn, M Mintz, SJ Hunter, H Yang, J Jones… - …, 2009 - Wiley Online Library
Purpose: Evaluate potential neurocognitive effects of adjunctive levetiracetam in children
with inadequately controlled partial‐onset seizures (POS). Methods: Randomized, double‐blind…
with inadequately controlled partial‐onset seizures (POS). Methods: Randomized, double‐blind…
Adjunctive levetiracetam in infants and young children with refractory partial‐onset seizures
JE Piña‐Garza, DR Nordli Jr, D Rating, H Yang… - …, 2009 - Wiley Online Library
Purpose: To evaluate the efficacy and tolerability of adjunctive levetiracetam in very young
children (aged 1 month to <4 years) with partial‐onset seizures inadequately controlled with …
children (aged 1 month to <4 years) with partial‐onset seizures inadequately controlled with …
Cognitive effects of adjunctive perampanel for partial‐onset seizures: A randomized trial
KJ Meador, H Yang, JE Piña‐Garza, A Laurenza… - …, 2016 - Wiley Online Library
Objective Assess cognitive effects of adjunctive perampanel in adolescents. Methods In this
double‐blind study (ClinicalTrials.gov identifier: NCT 01161524), patients aged 12 to <18 …
double‐blind study (ClinicalTrials.gov identifier: NCT 01161524), patients aged 12 to <18 …
High-frequency rTMS treatment increases white matter FA in the left middle frontal gyrus in young patients with treatment-resistant depression
…, L Zhang, Y Yin, J Liu, W Li, J Zhou, Z Li, H Yang… - Journal of affective …, 2012 - Elsevier
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment
for treatment-resistant depression (TRD), but its therapeutic mechanisms are unclear. …
for treatment-resistant depression (TRD), but its therapeutic mechanisms are unclear. …