Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats
Y Zhang, J Xu, YC Ruan, MK Yu, M O'Laughlin… - Nature medicine, 2016 - nature.com
Orthopedic implants containing biodegradable magnesium have been used for fracture repair
with considerable efficacy; however, the underlying mechanisms by which these implants …
with considerable efficacy; however, the underlying mechanisms by which these implants …
[HTML][HTML] Focal adhesion kinase signaling mediated the enhancement of osteogenesis of human mesenchymal stem cells induced by extracorporeal shockwave
…, H Chen, Z Huang, Y Zhang, M Yu, Y Chen, J Xu - Scientific reports, 2016 - nature.com
Extracorporeal shockwave (ESW) has been shown of great potential in promoting the
osteogenesis of bone marrow mesenchymal stem cells (BMSCs), but it is unknown whether this …
osteogenesis of bone marrow mesenchymal stem cells (BMSCs), but it is unknown whether this …
Biodegradable magnesium‐based implants in orthopedics—a general review and perspectives
Biodegradable Mg‐based metals may be promising orthopedic implants for treating challenging
bone diseases, attributed to their desirable mechanical and osteopromotive properties. …
bone diseases, attributed to their desirable mechanical and osteopromotive properties. …
Magnesium‐encapsulated injectable hydrogel and 3D‐engineered polycaprolactone conduit facilitate peripheral nerve regeneration
Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft
transplantation, a gold standard treatment in the current clinical setting. Nevertheless, …
transplantation, a gold standard treatment in the current clinical setting. Nevertheless, …
Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis
Y Li, J Xu, J Mi, X He, Q Pan, L Zheng, H Zu, Z Chen… - Biomaterials, 2021 - Elsevier
Critical size bone defects are frequently caused by accidental trauma, oncologic surgery,
and infection. Distraction osteogenesis (DO) is a useful technique to promote the repair of …
and infection. Distraction osteogenesis (DO) is a useful technique to promote the repair of …
Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects
Biopolymeric hydrogels have been widely used as carriers of therapeutic cells and drugs for
biomedical applications. However, most conventional hydrogels cannot be injected after …
biomedical applications. However, most conventional hydrogels cannot be injected after …
[HTML][HTML] Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically used …
medical and socioeconomic burdens. Intra-articular administration of agents is clinically used …
Bioactive glass-elicited stem cell-derived extracellular vesicles regulate M2 macrophage polarization and angiogenesis to improve tendon regeneration and functional …
H Xu, Y Zhu, AWT Hsiao, J Xu, W Tong, L Chang… - Biomaterials, 2023 - Elsevier
Effective countermeasures for tendon injury remains unsatisfactory. Mesenchymal stem cell-derived
extracellular vesicles (MSC-EVs)-based therapy via regulation of Mφ-mediated …
extracellular vesicles (MSC-EVs)-based therapy via regulation of Mφ-mediated …
[HTML][HTML] Advanced Hydrogel systems for mandibular reconstruction
Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular
dysfunctions and huge psychological burdens to the patients. Considering the routine presence of …
dysfunctions and huge psychological burdens to the patients. Considering the routine presence of …
[HTML][HTML] Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis
Epididymal white adipose tissue (eWAT) secretes an array of cytokines to regulate the
metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on bone …
metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on bone …