Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

Y Zhang, J Xu, YC Ruan, MK Yu, M O'Laughlin… - Nature medicine, 2016 - nature.com
Orthopedic implants containing biodegradable magnesium have been used for fracture repair
with considerable efficacy; however, the underlying mechanisms by which these implants …

[HTML][HTML] Focal adhesion kinase signaling mediated the enhancement of osteogenesis of human mesenchymal stem cells induced by extracorporeal shockwave

…, H Chen, Z Huang, Y Zhang, M Yu, Y Chen, J Xu - Scientific reports, 2016 - nature.com
Extracorporeal shockwave (ESW) has been shown of great potential in promoting the
osteogenesis of bone marrow mesenchymal stem cells (BMSCs), but it is unknown whether this …

Biodegradable magnesium‐based implants in orthopedics—a general review and perspectives

JL Wang, JK Xu, C Hopkins, DHK Chow… - Advanced …, 2020 - Wiley Online Library
Biodegradable Mg‐based metals may be promising orthopedic implants for treating challenging
bone diseases, attributed to their desirable mechanical and osteopromotive properties. …

Magnesium‐encapsulated injectable hydrogel and 3D‐engineered polycaprolactone conduit facilitate peripheral nerve regeneration

Z Yao, W Yuan, J Xu, W Tong, J Mi, PC Ho… - Advanced …, 2022 - Wiley Online Library
Peripheral nerve injury is a challenging orthopedic condition that can be treated by autograft
transplantation, a gold standard treatment in the current clinical setting. Nevertheless, …

Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis

Y Li, J Xu, J Mi, X He, Q Pan, L Zheng, H Zu, Z Chen… - Biomaterials, 2021 - Elsevier
Critical size bone defects are frequently caused by accidental trauma, oncologic surgery,
and infection. Distraction osteogenesis (DO) is a useful technique to promote the repair of …

Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects

Q Feng, J Xu, K Zhang, H Yao, N Zheng… - ACS central …, 2019 - ACS Publications
Biopolymeric hydrogels have been widely used as carriers of therapeutic cells and drugs for
biomedical applications. However, most conventional hydrogels cannot be injected after …

[HTML][HTML] Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy

X Li, B Dai, J Guo, L Zheng, Q Guo, J Peng, J Xu… - Nano-micro letters, 2021 - Springer
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically used …

Bioactive glass-elicited stem cell-derived extracellular vesicles regulate M2 macrophage polarization and angiogenesis to improve tendon regeneration and functional …

H Xu, Y Zhu, AWT Hsiao, J Xu, W Tong, L Chang… - Biomaterials, 2023 - Elsevier
Effective countermeasures for tendon injury remains unsatisfactory. Mesenchymal stem cell-derived
extracellular vesicles (MSC-EVs)-based therapy via regulation of Mφ-mediated …

[HTML][HTML] Advanced Hydrogel systems for mandibular reconstruction

…, X Li, L Chang, Z Wang, W Zhu, Y Su, L Qin, J Xu - Bioactive materials, 2023 - Elsevier
Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular
dysfunctions and huge psychological burdens to the patients. Considering the routine presence of …

[HTML][HTML] Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis

B Dai, J Xu, X Li, L Huang, C Hopkins, H Wang… - Nature …, 2022 - nature.com
Epididymal white adipose tissue (eWAT) secretes an array of cytokines to regulate the
metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on bone …