Since the final decades of the last century, twin studies have made a remarkable contribution
to the genetics of human complex traits and diseases. With the recent rapid development in …

The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent
deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. …

An epigenetic profile defining the DNA methylation age ( DNA m age) of an individual has
been suggested to be a biomarker of aging, and thus possibly providing a tool for assessment …

Expression of HOX transcript antisense intergenic RNA (HOTAIR)—a long non-coding RNA—has
been examined in a variety of human cancers, and overexpression of HOTAIR is …

The genetic contribution to the variation in human lifespan is ∼25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence population …

Insulin resistance in skeletal muscle is a major risk factor for the development of type 2
diabetes in women with polycystic ovary syndrome (PCOS). In patients with type 2 diabetes, …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we performed …

Most of the complex traits including aging phenotypes are caused by the interaction between
genome and environmental conditions and the interface of epigenetics may be a central …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

This paper reviews the recent literature on genes and longevity. The influence of genes on
human life span has been confirmed in studies of life span correlation between related …