Background Vascular dementia is a common disorder resulting in considerable morbidity
and mortality. Determining the extent to which genes play a role in disease susceptibility and …

The frequency of inherited bilateral autosomal recessive non-syndromic hearing loss (ARNSHL)
in Pakistan is 1.6/1000 individuals. More than 50% of the families carry mutations in …

Osteogenesis imperfecta (OI) is an inherited heterogeneous rare skeletal disorder characterized
by increased bone fragility and low bone mass. The disorder mostly segregates in an …

Congenital insensitivity to pain (CIP) and hereditary sensory and autonomic neuropathies (HSAN)
are clinically and genetically heterogeneous disorders exclusively or predominantly …

Allelic frequencies of 182 tri‐ and tetra‐autosomal microsatellites were used to examine
phylogenetic relationships among 19 extant human populations. In particular, because the …

Three populations from northern Pakistan, the Burusho, Kalash, and Pathan, claim descent
from soldiers left behind by Alexander the Great after his invasion of the Indo-Pak …

Globally, Pakistan with population of around 180 million moved up two spots to 6th in the list
of countries with the highest number of tuberculosis (TB) patients in the world according to …

Hepatitis C virus (HCV) infection is prevalent throughout the world and interferon (IFN)-based
treatments are currently the only therapeutic option. However, depending upon variations …

Epstein Barr virus (EBV)-transformed lymphoblastoid cell lines are commonly used to provide
an inexhaustible supply of DNA. We examined microsatellite instability in these cell lines …

Introduction Rheumatoid arthritis is an autoimmune disease with poorly understood
pathophysiology. Genetic components of disease etiology, especially human leukocyte antigen (HLA…