Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif-containing …

Ethnopharmacological relevance Xuebijing injection (XBJ), a Chinese herbal medicine
containing extracts from 5 herbs, is frequently used as an add-on with standard therapies to treat …

Senescent astrocytes accumulate with aging and contribute to brain dysfunction and diseases
such as Alzheimer's disease (AD), however, the mechanisms underlying the senescence …

Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the
Hippo pathway and functions in controlling the size of multiple organs, such as liver during …

Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes visual
disability. Astrocytes are pivotal regulators of neuroinflammation in MS, and astrocytic yes-…

Abstract Treatment of glioblastoma using radiotherapy and chemotherapy has various
outcomes, key among them being cellular senescence. However, the molecular mechanisms of …

Cholesterols are the main components of myelin, and are mainly synthesized in astrocytes
and transported to oligodendrocytes and neurons in the adult brain. It has been reported that …

Glioma is currently the most widespread and malignant primary intracranial tumor, which is
characterized by high heterogeneity and high fatality rates. β-elemene, which is a bioactive …

Objective We aimed to investigate the roles and underlying mechanisms of YAP in the
proliferation of neuroblastoma cells. Methods The expression level of YAP was evaluated by …

The homeostasis of glutamate is mainly regulated by the excitatory amino acid transporters (EAATs),
especially by EAAT2 in astrocytes. Excessive glutamate in the synaptic cleft caused …