[HTML][HTML] Treatment-Resistant Schizophrenia, Clozapine Resistance, Genetic Associations, and Implications for Precision Psychiatry: A Scoping Review

J Ying, QH Chew, RS McIntyre, K Sim - Genes, 2023 - mdpi.com
Treatment-resistant schizophrenia (TRS) is often associated with severe burden of disease,
poor quality of life and functional impairment. Clozapine is the gold standard for the …

Genetic polymorphism of IL-17F rs763780 contributes to the susceptibility to bipolar disorder but not to schizophrenia in the Turkish population

Y Oyaci, HM Aytac, M Pehlivan… - … , Nucleotides & Nucleic …, 2023 - Taylor & Francis
This study aims to investigate the genetic polymorphism in the interleukin-17F (IL-
17F)(rs763780, 7488 A/G) gene in bipolar disorder (BD) and schizophrenia (SCZ) patients …

Quantitative detection of methylated SOCS-1 in schizophrenia and bipolar disorder considering SOCS-1 -1478CA/del polymorphism and clinical parameters

HM Aytac, S Pehlivan, M Pehlivan, Y Oyaci - Irish Journal of Medical …, 2023 - Springer
Background We aimed to investigate the quantitative detection of methylated suppressor of
cytokine signaling-1 (SOCS-1) in schizophrenia (SCZ) and bipolar disorder (BD) …

[HTML][HTML] Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellness

C Wang, D Western, C Yang, M Ali, L Wang… - Research …, 2023 - ncbi.nlm.nih.gov
Brain metabolism perturbation can contribute to traits and diseases. We conducted the first
large-scale CSF and brain genome-wide association studies, which identified 219 …

[HTML][HTML] Association of intron 4 VNTR polymorphism in the NOS3 gene with rapid cycling and treatment resistance in bipolar disorder: a case-control study

HM Aytac, M Pehlivan, Y Oyaci, S Pehlivan - Neurosciences Journal, 2022 - nsj.org.sa
Objective: To evaluate the relationship between patients' clinical parameters, especially
clinical specifiers, and the intron 4 VNTR variant of the endothelial nitric oxide synthase …

[HTML][HTML] Interleukin-1 receptor antagonist (IL-1RA) and interleukin-4 (IL-4) variable number of tandem repeat polymorphisms in schizophrenia and bipolar disorder: an …

S Pehlivan, Y Oyaci, FC Tuncel, HM Aytac - Egyptian Journal of Medical …, 2022 - Springer
Background Pro-inflammatory/anti-inflammatory cytokine imbalance in cerebrospinal fluid or
plasma of schizophrenia (SCZ) and bipolar disorder (BD) patients has been documented …

IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings

S Pehlivan, HM Aytac, AF Nursal… - … Nucleotides & Nucleic …, 2024 - Taylor & Francis
Study results supported that immuno-inflammatory pathways in the brain and environment
contribute to the etiopathogenesis of bipolar disorder (BD), a chronic affective disease. Our …

[PDF][PDF] Evaluation of Serum Complement Levels and Factors Affecting Treatment Resistance in Patients with Schizophrenia

M Goker, HM Aytac, O Guclu - Psychiatry and …, 2023 - psychiatry-psychopharmacology …
Background: There are increasing investigations about the potential role of the complement
system in disorders affecting the central nervous system, including schizophrenia. Therefore …

Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population

K Ozdilli, HM Aytac, FC Tuncel, Y Oyaci… - Neurosciences …, 2024 - nsj.org.sa
Objectives: To evaluate the genetic polymorphisms in IL-2 and IL-2RA genes in
schizophrenia (SCZ) patients by comparing them with healthy controls. Methods: A sample …

Mannose-binding lectin conjugated to quantum dots as fluorescent nanotools for carbohydrate tracing

CN Lima, WF Oliveira, PMM Silva… - … and Applications in …, 2022 - iopscience.iop.org
Quantum dots (QDs) have stood out as nanotools for glycobiology due to their photostability
and ability to be combined with lectins. Mannose-binding lectin (MBL) is involved in the …