Objectives: To evaluate the efficacy of valproic acid (VPA) in a cohort of children below 2
years of age. We also aim to review the characteristics of such patients and the role and …

Short-Term Side Effects of Low Dose Valproate Monotherapy in Epileptic Children: A
Prospective Study - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Valproic acid (VPA) is considered to be a drug of first choice and one of the most frequently-
prescribed antiepileptic drugs worldwide for the therapy of generalized and focal epilepsies …

In certain pediatric patients on valproic acid, therapeutic range (50-100 μg/mL) is maximized
or exceeded to achieve better seizure control. This study compared incidence of common …

Purpose: Valproate has been widely used in controlling various kinds of seizures.
Intravenous forms of valproate control seizures in a more rapid and efficacious pattern than …

Holland KD, Monahan S, Morita D, Vartzelis G, Glauser TA. Valproate in children with newly
diagnosed idiopathic generalized epilepsy. Acta Neurol Scand: 2010: 121: 149–153.© 2009 …

This article reviews relevant pharmacologic and clinical information gathered for valproate
since it was introduced into clinical practice 37 years ago and the application of this …

Roles of intravenous administration of valproate in status epilepticus and serial seizures are
documented in adults and children. Pharmacokinetic parameters are necessary to predict …

Background/aim It is controversial whether the endocrine dysfunction in epilepsy patients is
caused by the epilepsy itself, the antiepileptic therapy, or both. We prospectively evaluated …

Six neonates with prolonged, intractable seizures were treated with valproic acid (VPA).
Each patient had received maximum doses of phenobarbital (> 40 μg/ml), and five patients …