We would like to discuss the recent publication by Aytac et al1 entitled 'Association of intron
4 VNTR polymorphism in the NOS3 gene with rapid cycling and treatment resistance in …

Objective: To evaluate the relationship between patients' clinical parameters, especially
clinical specifiers, and the intron 4 VNTR variant of the endothelial nitric oxide synthase …

Abstract Background/Aims: Several lines of evidence point to the role of neurobiological
mechanisms and genetic background in bipolar disorder (BD). The interleukin-1 receptor …

There is strong evidence demonstrating that genetic inheritance is associated with higher
susceptibility to bipolar disorder (BD), but the interaction between gene polymorphisms and …

Bipolar disorder (BD) is a chronic and disabling disorder characterized by manic,
hypomanic, or depressive episodes, with an estimated lifetime prevalence ranging from 1 …

Results of genome‐wide association studies (GWASs) for bipolar disorder (BD) have
indicated ANK3 as one of the most promising candidates for a susceptibility gene. In this …

The pleiotropic messenger molecule nitric oxide (NO) has been implicated in a variety of
higher CNS functions, including learning, memory, and emotionality. In the human brain, NO …

Abstract Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes
of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I …

Background: Bipolar disorder (BD) is a major psychiatric disorder characterized by
alternating mood episodes, including major depressive, hypomanic, and manic episodes …

Molecular Psychiatry years, with no history of mental illness or substance abuse. The mean
duration of education was 1372 years, 1272 years and 1573 years, in bipolar, schizophrenic …