Objectives: To explore the clinicopathological features and prognosis of multifocal high-
grade gliomas (M-HGGs) with H3F3A mutation in adults. Methods: Four adult patients with …

Abstract H3K27M and H3. 3G34R/V mutations have been identified in pediatric high-grade
gliomas (pHGG), though extraneural metastases are rarely reported and poorly …

Abstract H3F3A G34 (H3. 3 G34)-mutant high-grade gliomas (HGG) are rare, and newly
recognized infiltrating gliomas of the cerebral hemisphere. Here, we report the …

Recent studies have identified that K27M mutation in either the H3F3A or HIST1H3B genes,
which encode the histone H3 variants H3. 3 and H3. 1, define the majority of diffuse gliomas …

Purpose H3 K27 mutations, most commonly in H3F3A, are common in diffuse midline
glioma. The exact frequency of these mutations in adults with gliomas in the midline location …

The first patient is a 30-year-old woman who presented with headaches and symptoms of
increased intracranial pressure. Imaging demonstrated a heterogeneously enhancing mass …

Diffuse midline glioma (DMG), H3 K27M mutant (WHO grade IV) is listed as a separate CNS
tumor entity since 2016 [5], after large sequencing efforts had discovered H3 K27M …

Background Multifocal manifestation of high-grade glioma is a rare disease with very
unfavourable prognosis. The pathogenesis of multifocal glioma and pathophysiological …

We identified 16 HGG (11 glioblastomas, 3 anaplastic astrocytomas and 2 anaplastic
gangliogliomas, 16/30, 53%) and 1 diffuse astrocytoma harboring H3F3AK27M mutations …

Pediatric high‑grade glioma (HGG) is a type of malignancy that carries a poor prognosis.
The genetic analysis of HGGs has previously identified useful mutations, the targeting of …